The North American Mississippi Valley Loess Plains are a Level III ecoregion designated by the Environmental Protection Agency (EPA) in six U.S. states. The region lies primarily on the eastern border of the Mississippi Alluvial Plain, from the Ohio River in western Kentucky, through Tennessee and Mississippi, to Louisiana. A separate unit that includes Crowley's Ridge occurs west of the river in Arkansas and Missouri. It has been divided into four Level IV ecoregions.